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Prefrontal cortex development in adolescence

Adolescent maturation of the prefrontal cortex: Role of

  1. Development within the prefrontal cortex (PFC), in a process that is conserved in mammals, continues throughout adolescence. Synaptic density increases throughout the juvenile period, peaking at the onset of puberty, where pruning of synapses yields an overall decrease in synaptic number in the mature brain
  2. changes in the brain during the adolescent period as well as investigate how intrinsic and extrinsic factors may disrupt this development. In chapter 2,adolescents and adults were compared in a behavioral task dependent on the medial prefrontal cortex (mPFC). Adolescents were able to perform the task
  3. As the prefrontal cortex matures, teenagers can reason better, develop more control over impulses and make judgments better. The second wave of synapse formation described by Giedd showed a spurt of growth in the frontal cortex just before puberty (age 11 in girls, 12 in boys) and then a pruning back in adolescence
  4. The prefrontal cortex is one of the last regions of the brain to reach maturation. This delay may help to explain why some adolescents act the way they do. The so-called executive functions of the human prefrontal cortex include
  5. During adolescence, myelination and synaptic pruning in the prefrontal cortex increase s, improving the efficiency of information processing, and neural connections between the prefrontal cortex and other regions of the brain are strengthened. However, this growth takes time and the growth is uneven. The Teen Brain: 6 Things to Know Figure 1
  6. During adolescence, myelination and synaptic pruning in the prefrontal cortex increases, improving the efficiency of information processing, and neural connections between the prefrontal cortex and other regions of the brain are strengthened. However, this growth takes time, and the growth is uneven

One of the key differences between adult and adolescent brains, highlighted by Kinscherff, is the lack of prefrontal cortex development in young brains. The prefrontal cortex controls humans' ability to: delay and reflect (the lack of development limits the amount of time juveniles will think before they act) The Prefrontal Cortex and Teen Brain Development The brain develops in a back-to-front pattern. Hence, prefrontal cortex development is the last part of the brain maturation process. As a result, teen brain development is not yet complete Throughout childhood and into adolescence, the cortical areas of the brain continue to thicken as neural connections proliferate. In the frontal cortex, gray matter volumes peak at approximately 11 years of age in girls and 12 years of age in boys, reflecting dendritic overproduction One of the brain regions that changes most dramatically during adolescence is called prefrontal cortex. So this is a model of the human brain, and this is prefrontal cortex, right at the front. Prefrontal cortex is an interesting brain area

This chapter outlines the issues associated with the development of prefrontal cortex in children and adolescents, and describes the developmental profile of executive processes across childhood. The prefrontal cortex plays an essential role in various cognitive functions and little is known about how such neural mechanisms develop during childhood yet So, the prefrontal cortex loses grey matter during adolescence. It has been proposed that this decline in grey matter volume partly reflects an important neurodevelopmental process: the loss of connections between brain cells (synapses) during development As the prefrontal cortex matures, teenagers can reason better, develop more control over impulses and make judgments better. In fact, this part of the brain has been dubbed the area of sober.. Changes in this part of the brain continue into early adulthood. Because the prefrontal cortex is still developing, teenagers might rely on a part of the brain called the amygdala to make decisions and solve problems more than adults do. The amygdala is associated with emotions, impulses, aggression and instinctive behaviour the prefrontal cortex have a rather different time course. Histological studies of monkey and human prefrontal cortex have shown that there is a pro-liferation of synapses in the subgranular layers of the prefrontal cortex during childhood and again at puberty, followed by a plateau phase and a sub-sequent elimination and reorganisation of.

Prefrontal cortical parvalbumin and somatostatin expression and cell density increase during adolescence and are modified by BDNF and sex Brain-derived neurotrophic factor (BDNF) is known to play a critical role early in the development of cortical GABAergic interneurons The development of the brain's prefrontal cortex is very important for complex behavioral performance. Development and maturation happen primarily during adolescence and reach peak around 25 years of age. The brain develops in a back to front manner, which means the prefrontal cortex is the last portion to fully develop

prefrontal systems. However, less is known about the neural basis of refinements in cognitive control proceeding from adolescence to adulthood. Accumulating evidence indicates that integration between hippocampus (HPC) and prefrontal cortex (PFC) supports flexible cognition and has a protracted neural maturation The brain works the same way, because it starts pruning away the synapses that it doesn't need in order to make the remaining ones much more efficient in communicating. In teenagers, it seems that this process starts in the back of the brain and moves forward, so that the prefrontal cortex, that vital center of control, is the last to be trimmed However, the frontal cortex, the area of the brain that controls reasoning and helps us think before we act, develops later. This part of the brain is still changing and maturing well into adulthood Significant improvements in cognitive control occur from childhood through adolescence, supported by the maturation of prefrontal systems. However, less is known about the neural basis of refinements in cognitive control proceeding from adolescence to adulthood 7 Characteristics of the Development of A Child's Prefrontal Cortex That Have a Profound Impact on Behavior: #1. The human prefrontal cortex is not fully developed until around the age of 25!!! Some researchers go as far as 30. I was so glad to hear this. I've always looked for an excuse for my behavior in college! Just saying

Adolescents with high OCD-related symptoms, for example, also showed reduced myelin growth, but in different areas of the prefrontal cortex - mainly the areas responsible for cognitive functions. Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction Nat Commun. 2019 Sep 13;10(1):4169. doi: 10.1038/s41467-019-12054-3. Authors Aritra. Manitt C, Eng C, Pokinko M, Ryan RT, Torres-Berrío A, Lopez JP et al (2013). dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients. Over the course of adolescence, the limbic system comes under greater control of the prefrontal cortex, the area just behind the forehead, which is associated with planning, impulse control and.

What happens to the prefrontal cortex during adolescence

Another circuit still under construction in adolescence links the prefrontal cortex to the midbrain reward system, where addictive drugs and romantic love exert their powers. Most addictions get their start in adolescence, and there is evidence that adolescent and adult brains respond differently to drugs The prefrontal cortex of a 15-year-old is very different from that of a 30-year-old, both physically and in how it's used. For many teens, the output of their underdeveloped decision processing centers may be as mild as choosing a bag of cheese puffs for lunch or a new purple hairdo

Is the brain of a teenager of age 15 completely developed

A further MRI study of 35 normally developing children (7-11 years), adolescents (12-16 years) and young adults (23-30 years) demonstrated a sharp acceleration in the loss of grey matter between childhood and adolescence in the dorsal prefrontal cortex and the parietal cortex (Sowell et al., 2001). In the frontal lobes, the decrease in. In the adolescent brain, the frontal and prefrontal cortex aren't accessed with the same rapidity as the adult brain, which is why adolescents can act more impulsively. The frontal and prefrontal cortex house important executive functions like judgment and decision-making There are a variety of functions for which the prefrontal cortex is responsible. Although significant development of the prefrontal region occurs during adolescence, experts argue that it continues until (at least) our mid 20s. Attention: The ability to focus on one thing, while ignoring distractions is a function of our prefrontal cortex. Adults make much greater use of the prefrontal cortex—the mature decision-making part of the brain that responds to situations with rationality, sound judgment, and an awareness of long-term. T he biggest neurobiological difference between a young adult or adolescent and a fully matured adult is in the development of the prefrontal cortex. Let's look at what the prefrontal cortex does, and you will see why it is so important.. How different is a young adult from an adolescent? Comparing the two pictures makes it look like the answer is very different

Development - The Frontal Lobe

The rostral prefrontal cortex (RPFC), as other parts of the frontal cortex and the temporal cortices, shows prolonged structural development during adolescence (e.g. see Dumontheil et al., 2008 for review). The relationship between abstract thoughts and RPFC, in particular the RLPFC, during late childhood and adolescence will be the topic of. Although the development of the prefrontal cortex is the last step on the development checklist, teenagers undergo major changes in their limbic system—the area of the brain that controls. development cognitive and behavioral deficits •Prefrontal cortex •Adolescence: •Decreased volumes •Whole brain, gray matter, and hippocampus •Prefrontal cortex -increased and decreased volumes •Decreased prefrontal and insular cortical thickness •Larger amygdala volumes (in females

Understanding Teen Behavior: Maturation of the Brain's

Prefrontal Cortex Part of the frontal lobe: Helps with impulse control, judgments, reasoning One of the last areas of the brain to develop fully. During this time, there is an increased need for: Structure, mentoring, and guidance from adults Temporal Lobes Control hearing, understanding speech, sorting new information and short-term memory. The prefrontal cortex controls and overrides urges triggered by events in the environment. Excessively eating junk foods during adolescence could alter brain development, leading to lasting.

Third, another area of the brain, the lateral prefrontal cortex (PFC), is responsible for mature self-regulation and develops gradually over the adolescence period (Albert, et al., 2013). In one. The development of prefrontal cortex functions in adolescence: theoretical models and a possible dissociation of dorsal versus ventral subregions. In Nelson CA, Luciana MM, editors, The Handbook of Developmental Cognitive Neuroscience. 2nd ed. MIT Press. 200 AND PREFRONTAL CORTEX DEVELOPMENT DURING ADOLESCENCE Valerie L. Darcey, M.S. Thesis Advisor: John W. VanMeter, Ph.D. ABSTRACT Delivery of building blocks essential for brain development is critical for the normal development of the brain and behavior. Omega-3 (N3) fatty acids are essential nutrients, which can only be obtained from the diet

A. the development of his prefrontal cortex and the support of his peers B. the encouragement of his family and the myelination of his sensory cortex C. the development of his limbic system and the influence of male hormones D. changes in myelination in his brain and the guidance of an experienced coac Neuroscience has shown that a young person's cognitive development continues into this later stage and that their emotional maturity, self-image and judgement will be affected until the prefrontal. Within the frontal lobe is the middle prefrontal cortex which is largely responsible for helping to calm down big emotions. In order to do this, the middle prefrontal cortex develops nine crucial skills: Regulation of the body: the ability to have awareness of temperature, pain, hunger, etc. Attuned Communication: back and forth engaged.

Brain Development During Adolescence Lifespan Developmen

  1. e is particularly abundant during adolescence.
  2. development of the prefrontal cortex The brain develops in a back to front pattern, and the prefrontal cortex is the last portion of the brain to fully develop. This does not mean that children do.
  3. e dysfunctions in the prefrontal cortex (PFC) can contribute to diverse neuropsychiatric disorders, including ADHD, bipolar disorder, PTSD and depression. Disrupted dopa
  4. Adolescence is a developmental period characterized by unique behavioral phenotypes (increased novelty seeking, risk taking, sociability and impulsivity) and increased risk for destructive behaviors, impaired decision making and psychiatric illness. Adaptive and maladaptive adolescent traits have been associated with development of the medial prefrontal cortex (mPFC), a brain region that.
  5. Adolescence is a crucial period for the development of adaptive emotion regulation strategies. Despite the fact that structural maturation of the prefrontal cortex during adolescence is often assumed to underlie the maturation of emotion regulation strategies, no longitudinal studies have directly assessed this relationship

The maturation of the prefrontal cortex (PFC) during adolescence is thought to be important for cognitive and affective development and mental health risk. Whereas many summaries of adolescent development have focused on dendritic spin The literature reviewed suggests that fractionation of the functional neural systems plays a key role in the development of prefrontal cortex and such fractionating process has already commenced in preschool children. NEUROSCIENTIST 14(4):345-358, 2008. DOI: 10.1177/107385840831600 Investigating the Relationship between Long Chain Omega-3 Fatty Acids and Prefrontal Cortex Development during Adolescence In some manner, these abilities are associated with the normal function of the prefrontal cortex. All cortex in front of the central sulcus is frontal cortex. The primary motor cortex (Brodmann area [BA] 4) is the area in front of the central sulcus (Figure 5.1). Cognitive and affective development in adolescence. Trends in Cognitive. The human prefrontal cortex is amongst the most phylogenetically recent regions of the brain, and ontogenically, is one of the last to mature [1, 2].The region does not reach adult volume until 10 years of age [], and myelination continues to progress through adolescence well into early adulthood [].A rapid loss of prefrontal grey matter also occurs during adolescence [5, 6], which is commonly.

Morgunova A, Flores C. MicroRNA regulation of prefrontal cortex development and psychiatric risk in adolescence. Semin Cell Dev Biol. Academic press. 2021;S1084-9521(21)00084-7. 3 Adolescence has been characterized by risk-taking behaviors that can lead to fatal outcomes. This study examined the neurobiological development of neural systems implicated in reward-seeking behaviors. Thirty-seven participants (7-29 years of age) were scanned using event-related functional magnetic resonance imaging and a paradigm that parametrically manipulated reward values Adolescent Brain Development. The brain develops very rapidly in the first 3 to 5 years of life, and all the structure and building blocks are present by the age of 9. The different centres of the brain develop and become functionally connected over time. The last part to mature is the pre frontal lobe. This happens during adolescence Because the PFC is still developing during adolescence, teens don't have the impulse control of adults. The implication that impulse control is the primary function of the prefrontal cortex is echoed in other books about the teen brain. But this explanation dramatically understates what the PFC actually does Epidemiological research has pointed to adolescence as a critical period in the development of alcohol disorders. The prefrontal cortex (PFC) is a brain region that is not yet mature at the onset of human adolescence and continues to develop during this period, during which some individuals may be highly susceptible to the effects of alcohol

Brain Changes during Adolescence Adolescent Psycholog

connectivity of the medial prefrontal cortex (MPFC). The MPFC is commonly engaged by social and emotional processes (Amodio & Frith, 2006; Roy, Shohamy, & Wager, 2012), and is a key node in neuroscientific models of the development of the adolescent self-concept (Sebastian, Burnett, & Blakemore, 2008) Additionally, the ventral striatum and frontolateral prefrontal cortex showed patterns of activity that are more connected with each other during adolescence than early adulthood. While it is accepted that adolescents are less able to inhibit responding to tempting stimuli, it is unclear the specific neural mechanism that modulates this phenomenon The prefrontal cortex (PFC) is divided into subregions, including the medial and orbital prefrontal cortices. Dopamine connectivity in the medial PFC (mPFC) continues to be established throughout adolescence as the result of the continuous growth of axons that innervated the nucleus accumbens (NAcc) prior to adolescence. During this period, dopamine axons remain vulnerable to environmental.

The prefrontal cortex (PFC), the brain area responsible for executive functions and attention performance, is one of the last brain areas to mature and is still developing during adolescence There is no controlling neurological timetables of individual development. However, an introspective adolescent can certainly groom and nurture mature thought by questioning his own thoughts and behaviors. Examples: * The 'personal fable' (D. Elki.. The prefrontal cortex, cerebellum and reward systems. One key part of that trajectory is the development of the prefrontal cortex, a significant part of the brain, in terms of social interactions. Adolescent brain development is joined with the oscillations reduction in the delta and theta waves, and a rise in the alpha and beta waves. Based on the neuroanatomical findings and data from functional imaging studies, the authors bring up that adolescence is a phrase of imbalance in the nervous system since the prefrontal cortex matures. Autonomic arousal was uniquely heightened in adolescents. These behavioral patterns were paralleled by emergent engagement of the medial prefrontal cortex (MPFC) and striatum-MPFC connectivity during adolescence, which are thought to promote motivated social behavior in adolescence

Understanding the Adolescent Brain and Legal Culpabilit

  1. In depressed adolescents, higher self-compassion correlated with lower activity during sad v. neutral self-face recognition in the right dorsolateral prefrontal cortex (DLPFC), implying that less cognitive effort might be needed to avoid dwelling on sad self-faces and/or regulate negative affect induced by them. Moreover, higher self-compassion.
  2. OF course, most adolescents do not develop anxiety disorders, but acquire the skill to modulate their fear as their prefrontal cortex matures in young adulthood, at around age 25
  3. Crone and Dahl review functional imaging studies of cognitive, affective and social processing in adolescents. They suggest that, together with the development of cognitive control networks.

Teen Brain Development: Know the Facts Newport Academ

Chronic stress can cause permanent dysfunction of the prefrontal cortex and other brain structures (such as disrupting memory). The prefrontal cortex is particularly vulnerable to stress during adolescence, likely because this is the major normal developmental period of the prefrontal cortex (Lupien, McEwen, Gunnar & Heim, 2009) The prefrontal cortex plays a major role in adolescent affect. The right side may be activated by negative feelings, while the left side controls positive feelings; most of the time the two work in sync. The left side of the prefrontal cortex receives and filters information from the amygdala. If the amygdala sends a message of danger, the lef Adolescent development and pattern of recovery are described for a 15-year-old boy who sustained extensive right dorsolateral prefrontal cortex damage at age 7 from rupture and surgical treatment of a deep arteriovenous malformation. Follow-up evaluations at 4 years and most recently 8 years after illness have shown clear improvement in social. Development of the prefrontal cortex is not finished until we are somewhere in our mid-twenties. This is the part of the brain responsible for reasoning, impulse control, working memory, and rational decision making. The development of the prefrontal cortex has a huge impact on adolescent brain development and decision making. Source: quora.com The changes begin earlier in development closest to the brain stem in the rear of the brain, where the most basic functions begin to mature. Throughout adolescence, this process then moves slowly to areas of higher, more complicated functioning, and ends with the prefrontal cortex being the last to mature

Adolescent Maturity and the Brain: The Promise and

normal cognitive function.7,8 Dopamine innervation to the prefrontal cortex is known to develop throughout adolescence in both rodents and primates, and this protracted development may render the PFC dopamine circuitry particularly vulnerable to drug-induced alterations.9,1 Short- and long-term consequences of nicotine exposure during adolescence for prefrontal cortex neuronal Network function. Cold Spring Harbor Perspectives in Medicine. Vol. 2, December 2012, p. a012120. doi: 10.1101/cshperspect.a012120 As you learn to walk and talk, the frontal lobe makes more connections and stronger synapses are made. (7) The most rapid change in the frontal lobe occurs before adolescence, when neuron growth surges. The prefrontal cortex changes slowly during this time, and as the brain's myelin matures, it connects all regions of the brain together In early- and mid-adolescence, the brain undergoes considerable growth and pruning, moving generally from back to front areas of the cerebral cortex. Changes in Young Adulthood. At the same time that young adults are experiencing new levels of sophistication in thinking and emotional regulation, their brains are undergoing changes in precisely.

Video: Adolescent prefrontal cortex brain: Different than the

Development Period of Prefrontal Cortex IntechOpe

Explore the Prefrontal Cortex 3D BRAIN The most important brain area to become fully wired up in adulthood is the prefrontal cortex — the front portion of the frontal lobe. This area handles many of our higher-level cognitive abilities such as planning, solving problems, and making decisions Fig. 1. The traditional explanation of adolescent behavior has been suggested to be due to the protracted development of the prefrontal cortex (A). Our model takes into consideration the development of the prefrontal cortex together with subcortical limbic regions (e.g., nucleus accumbens) that have been implicated in risky choices and actions (B) Maturation in the prefrontal cortex continues throughout the early adulthood years (Chick & Reyna, 2012 Source: Chick, C. F. & Reyna, V. F. (2012). A fuzzy trace theory of adolescent risk taking. During adolescence, the prefrontal cortex undergoes dramatic structural reorganization, in which dendritic spines and synapses are refined, pruned, and stabilized. Understanding the molecular mechanisms that underlie these processes should help to identify factors that influence the development of psychiatric illness Limbic System Prefrontal Cortex Mostly developed by early adolescence. Mostly developed by mid-adoles-cence, but the capacity to function smoothly with the limbic system and other parts of the brain doesn't mature until the early 20s. Functions include • Risk taking • Motivation • Hunger • Sleep cycle • Long-term memor

The maturation of the prefrontal cortex (PFC) during adolescence is thought to be important for cognitive and affective development and mental health risk. Whereas many summaries of adolescent development have focused on dendritic spine pruning and gray matter thinning in the PFC during adolescence, we highlight recent rodent data from our. Changes in ventromedial prefrontal and insular cortex support the development of metamemory from childhood into adolescence Yana Fandakovaa,b,1,2, Diana Selmeczya,c, Sarah Leckeya,c, Kevin J. Grimmd, Carter Wendelkenb, Silvia A. Bungeb,e, and Simona Ghettia,c,1 aCenter for Mind and Brain, University of California, Davis, CA 95616; bHelen Wills Neuroscience Institute, University of California.

Adolescent brain development thIn

Sep. 16, 2019 — Female mice housed alone during adolescence show atypical development of the prefrontal cortex and resort to habitual behavior in adulthood, according to new research. These. During adolescence, large steps in development occur cognitively. Watching the TED talk and reading Chapter 5, I learned many key aspects to brain development. One of these transformations include changes in the prefrontal cortex. The prefrontal cortex is the large cerebral cortex that covers most of the brains frontal lobe. Its main functions include decision making, planning, social. Within the frontal cortex, it is the evolutionarily oldest sub-regions that mature first; the spanking new dorsolateral prefrontal cortex, for example, does not even begin to lose gray matter volume until the end of adolescence This pruning, which begins around age 11 in girls and 12 in boys, continues into the early or mid-20s, particularly in the prefrontal cortex, an area associated with higher functions such as.

Work In Progress - Adolescent Brains Are A Work In

10 Exercises for Your Prefrontal Cortex. 488802. Secure and Calm. Alert and Engaged. The brain has the amazing ability to change and improve itself. Peak brain development. [ 1] occurs in the early years (0-3), and again between the ages of twelve and twenty-four. We now know that humans also have the ability to continue to improve brain. Magnetic resonance imaging research has revealed that the prefrontal cortex changes a great deal during adolescence, as the brain's myelin matures and connects all regions of the brain together. This late growth and development is likely the reason that some otherwise intelligent and sensible teens engage in high-risk or excessive behaviors. These changes have been associated with the maturation of brain regions involved in the control of motivation, emotion, and cognition. Among these regions, the protracted development of the human prefrontal cortex during adolescence has been proposed to underlie the maturation of cognitive functions and the regulation of affective responses The most profound anatomical change in the cortex during adolescence was thinning, with the largest decreases observed in the parietal lobe. There were complex regional patterns of associations between changes in surface area and thickness, with positive relationships seen in sulcal regions in prefrontal and temporal cortices, and negative.

the neocortex. The protracted, relatively large, development of the prefrontal cortex is manifest in gross morphology as well as fine structure. In the developing individual, its late maturation is made most apparent by the late myelination of its axonal creases through childhood and early adolescence. Ac-cording to some recent imaging. Teens' brains make them more vulnerable to suicide. Suicide is the third leading cause of death among teens 15 to 19 years old, according to the National Centers for Disease Control and. AMPed-up adolescents: The role of age in the abuse of amphetamines and its consequences on cognition and prefrontal cortex development Sara R. Westbrook, Lauren K. Carrica, Asia Banks, Joshua M. Gulle During adolescence, dopamine levels in the limbic system increase and input of dopamine to the prefrontal cortex increases. The balance of excitatory to inhibitory neurotransmitters and increased dopamine activity in adolescence may have implications for adolescent risk-taking and vulnerability to boredom (see Cognitive development below)

Motivation and emotion/Book/2015/Prefrontal cortex and

Teenage brain development Raising Children Networ

The two most marked changes in the prefrontal cortex during adolescence are a pruning of synapses, correlated with a reduction in gray matter, and an increase in myelination that is correlated with an increase in white matter .There is a proliferation of prefrontal synapses that occurs firstly during early childhood and then later at puberty. Transcribed image text: Question 31 still developing in adolescence O Wernicke area O Primary gustatory cortex O Visual association area Prefrontal cortex Question 32 Inhibitory postsynaptic potentials (IPSPs) are associated with O hyperpolarization of the cell membrane. depolarization of the cell membrane. O repolarization of the cell membrane. The prefrontal cortex (PFC), the brain area responsible for executive functions and attention performance, is one of the last brain areas to mature and is still developing during adolescence. Smoking during adolescence increases the risk of developing psychiatric disorders and cognitive impairment in later life

What Is Involved in Frontal Lobe Development? (with pictures)Brain Research: Adolescents Learn More in Cooperative GroupsCompared to other parts of the brain, frontal lobe

The interplay between the prefrontal cortex and socioemotional system of the brain is relevant for adolescent development, as proposed by the Dual Systems Model. The medial prefrontal cortex has been implicated in the generation of slow-wave sleep (SWS), and prefrontal atrophy has been linked to decreases in SWS Adolescence (the stage between 10 and 24 years) is a period of life characterised by heightened sensitivity to social stimuli and the increased need for peer interaction. The physical distancing measures mandated globally to contain the spread of COVID-19 are radically reducing adolescents' opportunities to engage in face-to-face social contact outside their household The prefrontal cortex is a large area of the brain that takes up most of the frontal lobes in the right and left hemispheres. Like the rest of the cerebrum , the outer 0.07 to 0.19 inches (2 to 5 millimeters) of brain tissue are gray matter , specialized neurons that can send neural impulses at a much faster rate than the underlying white matter With an immature prefrontal cortex, even if teens understand that something is dangerous, they may still go ahead and engage in the risky behavior. Recognizing the asymmetry of development of the regions of the brain helps us to see adolescent risk-taking in a whole new light. Casey BJ, Jones RM, Hare TA. The Adolescent Brain the ventromedial prefrontal cortex or its connections are functionally maturing during adolescence in a manner that can be distinguished from maturation of other prefrontal regions. Development of these functions may continue into young adulthood. Intact functioning of the prefrontal cortex (PFC) is thought to b