Thinner RNFL measurements were associated with older age and increasing myopia. Caucasians tend to have thinner RNFL values when compared with Hispanics and Asians. SD-OCT analysis of the normal RNFL showed results similar to time domain OCT studies RNFL analysis: o Tomograms. o RNFL thickness plot* o Asymmetry Plot. o Table of measurements: RNFL thickness* ONH analysis: o Table of measurements: C:D (area, vertical, horizontal), disc area, rim area, and cup volume* Dimensions of analysis area—1 mm temporal to fovea: 7 x 7 mm. Macula analysis: o GCC thickness maps Purpose: To measure the thickness of the retinal nerve fiber layer (RNFL) of patients with retinitis pigmentosa (RP) and that of normal controls by scanning laser polarimetry with enhanced corneal compensation (GDxECC) and RTVue-optical coherence tomography (OCT). Methods: Fifty-two eyes of 26 patients were included. All patients underwent complete ophthalmological examinations and testing.
Macular OCT imaging of the ganglion cell and surrounding layers has shown promise in early diagnosis and screening of glaucoma where other changes may not be apparent. It is comparable to OCT-based peripapillary RNFL analysis in predicting risk of glaucoma development and should be used in conjunction with RNFL measurement for maximum diagnostic yield . 3, red arrows). The 4.1 mm and 4.7 mm RNFL circle scans confirm the presence and extent of this wedge defect (Fig. 4A, B, C) RNFL analysis on average RNFL thickness obtained borderline thinning in the right eye and significant thinning in the left eye. Hemifield and quadrant RNFL thickness appear to be thinning in the Inferior, Superior, and Nasal regions of the right and left eye according to the ISNT rule typical of glaucoma Retinal nerve fiber layer analysis via Markov random fields texture modelling. 2010 18th European Signal Processing Conference, 2010. Jiri Jan. Download PDF. Download Full PDF Package. This paper. A short summary of this paper. 37 Full PDFs related to this paper. Read Paper
The sector analysis provides information on the measurement's place in the normative distribution. For the printout shown, the results for the small 3.5-mm circle scan are seen (D). CONCLUSION. OCT is an evolving technology that provides measurements of the RNFL, the macula, and now, the ONH The RNFL analysis then averages the peripapillary scan measurements and produces 17 values for each scan set. These include mean RNFL thickness, 4 quadrant averages (temporal, superior, nasal, inferior), and 12 clock-hour averages. In this analysis, data from the mean RNFL thickness and quadrant averages are presented The retinal ganglion axons are an important part of the visual system, which can be directly observed by fundus camera. The layer they form together inside the retina is the retinal nerve fiber layer (RNFL). This paper describes results of a texture RNFL analysis in color fundus photographs and compares these results with quantitative measurement of RNFL thickness obtained from optical.
Statistical Analysis. For PERG, VEP, and RNFL parameters, 95% confidence limits were obtained from control data by calculating mean values +2 standard deviations (SD) for PERG, VEP IT, and RCT and mean values −2 SD for PERG A, VEP A, and RNFL-T (see Table 1) The effect of applying the myopic normative database for analysis of RNFL thickness in eyes with high myopia is signified by the decreases in false-positive errors in analysis of both the cRNFL profile and the RNFL thickness map . The improvement in specificities did not come at the cost of a reduction in sensitivity for detection of glaucoma A regression analysis or mixed effect analysis of a dependent variable (ie, RNFL thickness) is performed on follow-up measurements, providing a rate of progression over time. This method is less sensitive to sudden change and the variability among consecutive tests because it is neutralized by the overall rate of change The main advantage of macular GCIPL analysis over RNFL analysis lies in the fact macular GCIPL analysis can be of higher yield in those patients with peripapillary RNFL thinning like myopes, angioid streaks, serpiginous choroidopathy, post optic neuritis, etc. On the contrary, in patients with titled optic disc in high myopes, RNFL analysis may. Among eyes with advanced glaucoma, GCC analysis may be a better alternative over RNFL analysis in monitoring progression. 4,12,13,14. Another possible advantage of GCC scans over RNFL OCT is ease of data acquisition. RNFL OCT requires the subject to maintain fixation medially (offcenter) which may cause motion artifacts
. Results No significant difference was found in both groups on age, sex distribution, refractive error, intraocular pressure (IOP) and axial length The RNFL was thickest inferiorly (136.9±16.9 μm) and superiorly (135.4±19.3 μm), thinner nasally (83.0±18.0 μm), and thinnest temporally (72.5±13.4 μm). In univariate regression analysis, age (P = 0.013) and refraction (P<0.001) had a significant effect on RNFL thickness; age had a significant effect on refraction (P<0.001) In some eyes, there is a dark band on the retina corresponding to the area of narrowing of NRR (between yellow arrows in the picture below). They are areas of retinal thinning due to loss of some tissue there. They are called retinal nerve fiber layer (RNFL) defects. They usually correspond to defects in the visual field tests
In this presentation from AGS 2017, Dr. Michael Kook discusses the use of OCT in detecting glaucoma progression. The focus is on the retinal nerve fiber layer and nerve head The ganglion cell analysis has advantages over OCT of the retinal nerve fiber layer (RNFL) since it can be easily correlated with visual field defects and usually shows changes earlier The ganglion cell analysis should be interpreted with caution since it is prone to segmentation error . In addition, the GCL-IPL analysis of the macula demonstrates the severe thinning of the ganglion cell layer in the right eye (lower right image), which correlates with the patient's significant vision loss Guided Progression Analysis (GPA) compares RNFL thickness measurements from different visits. ZEISS GPA is the only progression analysis avail-able in both structure and function that differentiates between change due to normal variability and pro-gression due to disease. ONH and RNFL analysis from the optic disc SmartCube™
Neuroimaging manifestations have even been reported in asymptomatic children with SARS-CoV-2 infection.13 Our analysis of the optic nerve using OCT reveals an increase in peripapillary RNFL thickness, along with a decrease and an increase in macular RNFL and GCL, respectively, in children who recovered from COVID-19 Cirrus HD-OCT RNFL and ONH Analysis Report Based on the 6 mm x 6 mm data cube captured by the Optic Disc Cube 200x200 scan, this report shows assessment of RNFL and ONH for both eyes. 1 Key parameters, compared to normative data, are displayed in table format. 2 Nerve Fiber Layer (RNFL) thickness map is a topographical display of RNFL Cirrus. The RNFL thickness average analysis report, using the fast RNFL thickness scan with three sequential circular scans of 3.4 mm diameter over the optic disc, was performed. Before the scan the pupil size of each subject was determined under ambient conditions. Those below 4 mm were then dilated with 0.5% tropicamide Results: Mean RNFL thickness was 85.40±15.45µ in myopes and99.34±10.26µ in emmetropes. It was significantly less (Mean difference 13.94; 95% CI -18.93 to -8.94) in myopes compared to emmetropes. Quadrant wise analysis showed significant thinning in myopes in comparison to emmetropes except in temporal quadrant Analysis of the RNFL thickness deviation map—a color-coded map displaying areas of RNFL abnormalities—detects glaucoma with high sensitivity and specificity. Trend analysis of average and sectorial RNFL thicknesses, and event analysis of the RNFL thickness maps and the RNFL thickness profiles can be used to detect and follow diffuse and.
Two independent observers graded the RNFL visibility score and determined the location of RNFL defect on each image. Readings were taken from the superior and inferior areas. The diagnostic performances of multicolor, green-reflectance, and blue-reflectance images for detection of RNFL defect were compared with those of conventional fundus and. The most important point here is the ability to perform RNFL analysis with a reliable level of precision repetitively, even though the optic disc is not placed in the center during the scan. Signal Power. The value of the signal power is a value between 0 and 10 for the entire scan, with 10 being the maximum value Visual field analysis (30-2) was done by Humphrey's field analyzer (model- 740i). Axial length measured was by amplitude scan (MD - 1000 A, Ultrasonic Biometer Medaco). Dilated fundus examination was performed with +90D lens along with indirect ophthalmoscopy and scleral indentation. RNFL thickness was measured using Optical coherenc For RNFL analysis, the average thickness map with yellow or red color codes and the quadrant and clock-hour maps with ≥1 yellow- or red-colored sectors were considered abnormal. The abnormal RNFL deviation map was defined as a wedge-shaped, radiating colored pattern with ≥10 contiguous yellow or red superpixels in length and ≥2.
Analysis. Here, we see a patient with statistical abnormality of the retinal nerve fibre layer (RNFL) on OCT but normal optic nerves, visual fields, and ganglion cell analysis. The statistical abnormality arose due to split bundles or off-setting of the superior peak on RNFL thickness analysis when compared to age-matched controls Figures A-K are comparisons of RNFL thickness analysis, macular thickness analysis and ganglion cell complex analysis as represented by each model. The Future of OCT A significant challenge with OCT technology is keeping up with advances without losing previous data during system and software upgrades Analysis of progressive RNFL thinning is currently limited by the lack of adjustment for age-related RNFL thinning. 23,24 While age-related RNFL thinning in healthy eyes is unlikely to have a significant effect on the VF, any form of further RNFL loss in glaucomatous eyes may contribute to deterioration of visual function. It remains to be.
For statistical analysis the signiﬁcance level was set at p 0.05. We found a signiﬁcant RNFL thinning, both global and selective for each quadrant in AD compared to HC ( p = 0.05): average 92.09 ± 9.8 lm vs 98.18 ± 5.9 lm; superior quadrant 112.5 ± 17.3 lm vs 121.4 ± 12.5 lm; inferior quadrant 119 ± 16.5 lm vs 125.86 ± 10 lm; temporal. (B) A 'cooler' plot, showing diffuse RNFL loss. (C) Inferior temporal RNFL loss, showing asymmetry across the horizontal raphe Figure 4 Normative comparisons for a healthy (A-C) and a glaucomatous (D-F) eye. (A) TSNIT graph showing RNFL thickness is within (green) or above (white) normal limits. (B) 3.4mm diameter circle showing RNFL Figure 3 OCT Guided Progression Analysis (GPA) of retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness and visual field (VF) testing of the left eye of a patient with severe glaucoma illustrating glaucoma progression. On the right is a panomap consisting of combined RNFL and macular GCIPL deviation maps. We investigated structural injury patterns in the peripapillary retinal nerve fibre layer (p-RNFL) and ganglion cell inner plexiform layer (GCIPL) caused by ethambutol treatment. Sixty-four patients undergoing ethambutol treatment at Zhejiang Chinese Medicine and Western Medicine Integrated Hospital were recruited. Fourteen (14) exhibited visual dysfunction (abnormal group), and the remaining. The protocol for ONH was created for the evaluation of RNFL and ONH. The tomograph makes normally 75-90 disc scans. Circular scans were made around the ONH with diameter from 1.0 to 5.0 mm and after analysis, a RNFL map was constructed. After that, 13-30 radial scans were made to determine the boundaries of ONH and its structural variables
In conclusion, we demonstrated a new model for a DFT analysis of RNFL with Cirrus HD-OCT. It is a useful biomarker for diagnosing glaucoma in high myopic eyes, which is difficult by existing. RNFL and ONH Analysis ZEISS CIRRUS HD-OCT Nerve Fiber Layer (RNFL) thickness map is a topographical display of RNFL. An hourglass shape of yellow and red colors is typical of normal eyes. Key parameters, compared to normative data, are displayed in table format RNFL analysis is an essential part of the glaucoma evaluation, since, in reality, the RNFL is the tissue damaged by glaucoma. Structural damage almost always precedes functional damage, and the techniques described in this chapter can often detect the earliest damage, as well as detect progressive RNFL loss often before the visual field changes.1 The early detection of glaucoma and its.
CORDA-Enhanced SD-OCT Improves RNFL Analysis - Page 0 of 36 When a Technology Falters Find a Fix • Many clinicians rely upon the results of circumpapillary retinal nerve fiber layer (RNFL) measurements obtained with OCT to diagnose and manage their glaucoma patients In this study, the 3.5 mm diameter peripapillary RNFL was used for further analysis. Trabeculectomy Surgery for Glaucoma. Trabeculectomy with application of mitomycin C (MMC) (28/54) was performed by one single experienced surgeon according to the standard operating procedures of the department. A fornix-based approach was performed
RNFL analysis Circular scanning around ONH at a radius of 1. 73mm. Three scans are acquired and data is averaged and compared with normative data base of age matched subjects Scan begins temporally 21. RNFL thickness average analysis printout -7 zones • Zone -1-Pt Fast retinal nerve fibre layer (RNFL) protocol optical coherence tomography (OCT) showing average RNFL thickness with false colour coding to depict the data Statistical analysis Data analyses were done using STATA 11 (StataCorp, College Station,Texas, USA) and SPSS version 20 RNFL analysis. In both protocols, the scanned area was a 6-mm cube with no signal averaging. The quality of the obtained images was assessed by eval-uation of the signal strength (a value from 0 to 10 in arbitrary units) auto-matically provided by the system. Onl RNFL thinning was more severe in inferotemporal and superotemporal sectors in the study. Both average mean deviation and pattern standard deviation obtained by visual field examination showed a statistically significant negative correlation with average RNFL thickness by OCT analysis. CONCLUSION Thus, RNFL analysis by OCT is found to be a.
Disease: Multiple Sclerosis Sub-Domain: Imaging Diagnostics CRF: Imaging OCT Analysis - RNFL Thickness Analysis Displaying 1 - 14 of 14 . CDE ID CDE Name Variable Name Definition Short Description Question Text Permissible Values Description Data Type Disease Specific Instructions. St Luke's International Eye InstituteGlaucoma Lecture Serie Descartian Analysis: *(the physician's role) •The science of the intellect is universal, and there can only be one true method, which consists of separating what is already simple and clear in order then to attempt to understand that which is complex and obscure. The method is a collection of reliable, easy rules, observing whic
Evaluation of agreement between reference standards and Cirrus OCT GPA showed that when expert assessment of optic disc/RNFL photographs and/or VF analysis was used as the reference standard, the sensitivity and specificity of Cirrus OCT GPA to detect glaucoma progression were 25% and 88.61%, respectively OCT analysis of the ONH and RNFL is useful for early glaucoma detection. Among the three reference planes examined in this study, measurements analyzed at 150 μm above the RPE demonstrated the best performance for glaucoma detection and correlation with visual function. Compared with ONH measurements, RNFL thickness may be a better indicator. cup/disc ratio, cup volume and RNFL thickness in four quadrant (superior, inferior, nasal, and temporal). Statistical analysis Data analysis was performed using the IBM SPSS Sta-tistics ver. 22 (IBM Corp., Armonk, NY, USA). Descrip-tive analysis was used for the mean values and standard deviation (SD). All values will be tested for normal distri survey for visual RNFL analysis in fundus with respect to age and optic disc damage has been described by Jonas and Dichtl [ ]. A simple texture analysis for severe RNFL defects detection has been described and tested by Yogesan at al., [ ], on set of digitized fundus photographs with low resolution.Tuulonenetal.[ ]alsodescribedthemicrotextur
Similarly, the HRT 2 shows a normal Moorfields Regression Analysis and Glaucoma Probability Score, but the TCA Overview Report shows some highlighting for change in this area. The Stratus OCT exhibits a full RNFL map on TSNIT analysis, but the RNFL thickness deviation map does show the RNFL defect, which lies mostly outside the scanning circle LP248912-0 Retinal nerve fiber layer. The RNFL is formed from expansion of the fibers of the optic nerve and extends to the interior surface of the retina. The RNFL is divided into 4 quadrants when measured in each eye - temporal, superior, nasal, and inferior. Each 90 degree quadrant is further divided into three 30 degree sectors (clock hours) The RNFL thickness average analysis report, using the fast RNFL thickness scan with three sequential circular scans of 3.4 mm diameter over the optic disc, was performed. Before the scan the pupil size of each subject was determined under ambient conditions. Those below 4 mm were then dilated with 0.5% tropicamide The thin RNFL in the right eye is clearly visible in the OCT image (figure 4 - OD white arrow). The left eye shows significant loss of the temporal RNFL, consistent with severe glaucomatous damage (figures 4, 5 & 6 - OS white/black arrows). Figure 4 RNFL OCT scans Figure 5 RNFL thickness profiles Figure 6 RNFL classification101 charts Figure
Association analysis. We initially explored associations between RNFL thickness and various ophthalmological and cognitive measures (). 1602 twins of 908 families (mean age 56.4 years; range 18. In multivariate analysis, RNFL defect volume and RNFL defect volume deviation were signiﬁcantly associated with the mean deviation in visual ﬁeld tests. CONCLUSIONS. Retinal nerve ﬁber layer defect volume deviation is a useful tool for diagnosing glaucoma and monitoring RNFL change. In early stage of RNFL loss, RNFL defect volum OCT Analysis - RNFL Thickness Analysis [Study Name/ID pre-filled]Site Name: Subject ID: General Instructions - OCT Analysis - RNFL Thickness Analysis CRF Module. MS CDE Version 3.0Page 1 of 3. Macular cube scan pattern (choose only one): Cirrus RNFL Thickness Analysis: Optic Disc Cube Scan 200 x 200 Measure BMO-MRW and RNFL with SD-OCT. If the BMO-MRW and RNFL is below the normal range and those with glaucomatous optic disc and two consecutive abnormal visual field test results with open angles on gonioscopy, glaucomatous optic neuropathy, RNFL defects congruent with visual field defects, they will be classified into glaucoma patients A previous meta-analysis 28 of seven different articles studying the RNFL thickness in AD compared with controls, all of which used TD-OCT, determined that there is a significant reduction in RNFL thickness in AD patients compared with HC, overall and in all four individual quadrants
For example, the ganglion cell complex is a segmentation of the inner retina including the ganglion cell, inner plexiform and RNFL. The ganglion cell analysis is a segmentation that includes only the ganglion cell and inner plexiform layers (GCIPL). Scans are centered on the fovea and the thickness may be reported as sector, average and minimum Results: Temporal RNFL thickness showed no association with AL in either glaucomatous or nonglaucomatous eyes. Nasal thinning was most strongly associated with glaucoma in myopic eyes. Both myopic glaucomatous and nonglaucomatous eyes had a mean RNFL thickness of 16-22 μm thinner than mean RNFL thickness of normal AL eyes Results from the meta-analysis of OCT studies by Coppola et al. in MCI patients supported decay of peripapillary RNFL and a decline in macular thickness. Studies by Paquet et al. also reported a statistically significant reduction of RNFL thickness in patients with MCI compared to controls
In particular, RNFL thickness is a useful parameter for monitoring glaucoma progression analysis. It should be understood that the embodiments, examples and descriptions have been chosen and described in order to illustrate the principals of the invention and its practical applications and not as a definition of the invention RNFL can be used to estimate the RNFL thickness for glaucoma detection. Fig. 1 Process of retina affected by glaucoma 2. RELATED WORK Authors  presented the measurement of RNFL thickness and segmentation of RNFL using OCT images for glaucoma detection. In this work, both normal and abnormal images are taken for analysis
Myelinated retinal nerve fiber layers (MRNF) are retinal nerve fibers anterior to the lamina cribrosa that, unlike normal retinal nerve fibers, have a myelin sheath. Clinically, they appear to be gray-white well-demarcated patches with frayed borders on the anterior surface of the neurosensory retina. MNFL are present in 0.57 to 1% of the population and can occur bilaterally in. RNFL thickness was measured using the RNFL thickness scan algorithm consisting of 512 A scans centered on the disc. Peripapillary RNFL thickness parameters calculated at a 3.4-mm-diameter circle using the RNFL thickness serial analysis protocol included the average RNFL thickness, superior and inferior maximum thickness, superior and inferior. Increased area centralis RNFL thickness correlated significantly with pERG deficits (r2= 0.43, p=0.03). Analysis of peripapillary RNFL showed significantly decreased thickness (p=0.0098), which did not correlate with pERG deficits. Analysis of area centralis showed progressive loss of RNFL thickness at 90 and 180 days post compression
RNFL thickness is also shown to be a useful biomarker in Parkinson`s disease, where the amount of thinning correlates with disease severity and is an indicator for progression. A meta analysis of 13 studies concluded that the RNFL thickness of Parkinson`s patients is remarkably decreased compared to control group coherence tomography retinal nerve fiber layer thickness measurements. Knight OJ, Chang RT, Feuer WJ, Buden Analysis of RNFL thickness among different refractive states using OCT; Analysis of RNFL thickness among different refractive states using OCT. Authors . Hamed Safa Omer Wd Haj Elrahman, Nuha Mohamed Fath Qureshi, Manzoor, Ahmad Elmadina, Abd Elaziz, Mohamed Ahmad, Muhammad Ijaz Affiliation Comparative diagnostic analysis. A total of 150 myopic eyes of 138 patients ( 24 mm) underwent multicolor imaging by Spectralis® optical coherence tomography (OCT; Heidelberg Engineering GmbH, Heidelberg, Germany). Two independent observers graded the RNFL visibility score and determined the location of RNFL defect on each image The purpose of this study is to collect preliminary data on retinal nerve fiber layer and ganglion cell layer damage in multiple sclerosis (MS) patients, using optical coherence tomography (OCT). For this study the Zeiss Cirrus OCT Imaging System will be used. The same system will be used consistently for the duration of the study
CORDA-Enhanced SD-OCT Improves RNFL Analysis - Page 33 of 36 About us Review of Optometry has teamed up with well-known optometrist, Dr. Jerry Sherman, Past President of Optometric Retina Society to create this unique website serving the optometric community with weekly Retina Case Reports In the analysis of red-free RNFL photographs, the average angular widening of the localized RNFL defect towards the macula was 3-4°. In addition, 42% of patients with PPG showed structural progression with the angles α and β changing at mean rates of approximately 1°/year The average mean deviation on visual field testing for patients with glaucoma was -9.0 ± 5.1db. Global CORDA parameter HR2 displayed strong correlation with mean RNFL thickness (r = 0.70, P. Segmental Analysis With Reference to Colour-coded Normative Data. The RNFL was considered abnormally thin for an individual if its value was less than the 5th percentile of the age- and optic disc size-adjusted normal values and thick if it was more than the 95th percentile
The obtained result L RNFL * (θ,ρ), the ROI in the polar coordinate system (Figure 7), is the basis for further analysis. Based on the presented exploratory factor analysis and the proposed method of image analysis and processing, the features representing different classes (Figure 4 , Table 3 ), associated with L RNFL * ( θ,ρ ), were. Thinning of the RNFL in one quadrant was seen in 12 eyes (27.9%) of 10 patients (41.7%), and thinning in two or more quadrants was seen in 12 eyes (27.9%) of 8 patients (33.3%). It should be noted that RNFL thinning was present in 7 (87.5%) of 8 patients who were older than 35 years of age Myopia is a major public health problem that is growing worldwide .Many studies have investigated structural changes in myopic eyes, mainly the thinning of the peripapillary retinal nerve fiber layer (RNFL) and deformation of the optic nerve head [2,3,4,5].The RNFL thickness of adult myopia is believed to become thinner with an increasing refractive degree of the eyes , while others. The Optic Nerve Head Analysis (ONH) Normative Database compares optic nerve head measurements in a population of normal subjects. It was derived from a post-hoc analysis of the 200 x 200 optic disc cube scans from 282 eyes of the 284 eyes included in the RNFL normative database referenced in a previous 5 10(k), K083291. The normativ RNFL TREND ANALYSIS Baseline and subsequent visits can be examined over time. Trends are provided for disc parameters and RNFL thickness along with a reference database comparison. Maestro2 provides rich analysis of the macular and disc regions. Reports can be auto exported
Analysis of variance (ANOVA) was used to determine a significant difference in foveal thickness and RNFL thickness sector data sets (JMP V8.02, SAS Institute Inc., Cary, USA). Results Ophthalmologic examination showed signs of confounding ocular pathology in none of the healthy controls but in three of the patients CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Glaucoma is a progressive optic neuropathy characterized by a loss of retinal ganglion cells, thinning of the retinal nerve fiber layer (RNFL), thinning of the neuro-retinal rim, and enlarged cupping. Scanning laser devices like the OCT can be helpful to detect these changes Analysis of mean RNFL thickness in 3 studies between MCI patients and healthy controls found less, but still significant, heterogeneity (I 2 = 70.99%) across the studies, so the data were pooled through the random effects model The optical coherence tomography (OCT), based on interferometry analysis, is a major achievement particularly for documentation of quantitative changes in the optic nerve head: it allows a measure of the retinal nerve fiber layer thickness (RNFL)
Average RNFL thickness and inferior RNFL thickness each correlated well with mean deviation (r = 0.71, P < .001). Superior RNFL thickness also correlated well with mean deviation (r = 0.64, P < .001) The pattern of RNFL progression was evaluated by comparing the baseline RNFL thickness deviation map and the RNFL thickness change map. Visual field progression was defined by trend analysis of visual field index and event analysis based on the Early Manifest Glaucoma Trial criteria RNFL analysis was done using spectral domain OCT (OptoVue). The HVF changes were compared with the findings of RNFL in OCT. The patients were divided into mild, moderate and severe glaucoma based on the mean deviation values in the visual field analysis given by Hodapp et al,  (Table no. 1). The results were analysed by using MS Excel 2010. Therefore, a meta-analysis was performed to evaluate the RNFL changes in OSAS measured in vivo. METHODS: Pertinent studies were identified by a comprehensive search of PubMed, Embase, Web of science, Cochrane library, Scopus, and Chinese biomedical disc databases from inception to August 2016 for RNFL analysis and the macular cube protocol was used for ganglion cell layer analysis. Only good quality scans withasignalstrengthof wereusedfortheanalysis.e mean, sectoral (temporal, superior, nasal, and inferior), and clock hour pRNFL thickness measurements were analyzed. e mean, minimum, and sectoral (superior, superonasal